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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
24.55
Human Site:
S638
Identified Species:
45
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
S638
G
F
V
F
T
P
R
S
R
E
E
L
P
P
N
Chimpanzee
Pan troglodytes
XP_522169
734
81883
S680
S
F
T
F
I
P
R
S
R
E
E
L
P
D
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
S692
S
F
T
F
I
P
R
S
R
E
E
L
P
D
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
S638
G
F
V
F
T
P
R
S
R
E
E
L
P
P
N
Rat
Rattus norvegicus
P19686
690
77548
S637
G
F
V
F
T
P
R
S
R
E
E
L
P
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
S638
G
F
V
F
T
P
R
S
R
E
D
L
P
P
N
Chicken
Gallus gallus
XP_420375
688
77848
S636
D
F
V
F
T
P
R
S
R
E
E
L
P
P
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
G581
G
D
A
Y
C
V
A
G
G
L
H
R
K
I
D
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
R630
N
I
S
P
T
T
H
R
L
L
E
D
H
P
E
Fruit Fly
Dros. melanogaster
Q07093
676
75644
P623
G
F
E
F
E
L
Q
P
R
D
P
S
F
L
P
Honey Bee
Apis mellifera
NP_001011650
699
78655
R648
S
G
F
D
L
E
P
R
Q
K
E
F
L
P
K
Nematode Worm
Caenorhab. elegans
O02298
688
78384
R614
W
E
L
C
S
R
P
R
S
G
E
Q
T
I
D
Sea Urchin
Strong. purpuratus
P16065
1125
126238
G1074
G
Y
E
L
E
D
R
G
L
V
P
M
N
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
73.3
N.A.
73.3
N.A.
100
100
N.A.
93.3
93.3
N.A.
6.6
20
26.6
13.3
6.6
13.3
P-Site Similarity:
100
73.3
N.A.
73.3
N.A.
100
100
N.A.
100
93.3
N.A.
20
20
40
26.6
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
8
0
8
0
0
0
8
8
8
0
16
16
% D
% Glu:
0
8
16
0
16
8
0
0
0
54
70
0
0
0
8
% E
% Phe:
0
62
8
62
0
0
0
0
0
0
0
8
8
0
0
% F
% Gly:
54
8
0
0
0
0
0
16
8
8
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
8
0
8
0
0
% H
% Ile:
0
8
0
0
16
0
0
0
0
0
0
0
0
16
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
16
% K
% Leu:
0
0
8
8
8
8
0
0
16
16
0
54
8
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
54
% N
% Pro:
0
0
0
8
0
54
16
8
0
0
16
0
54
54
8
% P
% Gln:
0
0
0
0
0
0
8
0
8
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
8
62
24
62
0
0
8
0
0
0
% R
% Ser:
24
0
8
0
8
0
0
54
8
0
0
8
0
0
0
% S
% Thr:
0
0
16
0
47
8
0
0
0
0
0
0
8
0
0
% T
% Val:
0
0
39
0
0
8
0
0
0
8
0
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _